Bioactive Small Molecules
Medchemexpress LLC HY-12215 25mg , Lorlatinib CAS:1454846-35-5 Purity:>98%
HY-12215 25mg Lorlatinib CAS: 1454846-35-5 Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive ROS1/ALK inhibitor. Lorlatinib has Kis of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALKL1196M, respectively. Lorlatinib has anticancer activity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY EmrIcasn 25mg
A pan-caspase inhibitor; prevents cold ischemia-warm reperfusion-induced SEC apoptosis and inhibits caspase-3 activation in rat liver at 10 mg/kg ex vivo; reduces ALT levels (ED50s = <0.01-0.38 mg/kg) as well as apoptosis and caspase activity in a dose-dependent manner in the α-Fas mouse and D-Gln/LPS rat models of liver injury; reduces caspase-3 and caspase-8 activity, serum ALT levels, hepatocyte apoptosis, and hepatic fibrogenesis in a mouse model of high-fat diet-induced NASH; enhances islet engraftment and lowers post-transplant fasting glucose levels in a porcine islet autotransplant model
Medchemexpress LLC Gne-235 | 3036574-72-5 | 98.5% | 244.29 g·mol⁻¹ | C13H16N4O | 10 MG
GNE-235 is a small-molecule probe that selectively targets the second bromodomain of PBRM1. It binds the bromodomain with a reported KD of 0.28 ± 0.02 μM and is intended for cellular evaluation of PBRM1 function. The compound is supplied as a solid with documented purity, solubility, and storage recommendations for research use.
- Selective for the second bromodomain of PBRM1.
- Reported KD 0.28 ± 0.02 μM for target binding.
- Molecular weight 244.29 g·mol⁻¹; formula C13H16N4O.
- Purity typically 98.45% as supplied.
- Soluble in DMSO at ~100 mg/mL; ultrasonic agitation recommended.
- Powder storage at -20°C for long-term stability; in solvent store at -80°C for up to 6 months.
Apexbio Technology LLC ALW-II-41-27, 5mg CAS# 1186206-79-0
ALW-II-41-27 is a potent inhibitor of EPH family kinases, with an IC50 value of 11 nM to EPHA2 [1] [2].EPH family proteins are key regulators of both disease and normal development. EPH receptors are involved in many intracellular signaling pathways such as PI3K/AKT/mTOR, RAS/RAF/MAPK, FAK, SRC, ABL, and RHO/RAC/CDC42 [2].In H358 cells, treatment with ALW-II-41-27 at a concentration of 1 M within 15 minutes impaired the tyrosine phosphorylation of the EPHA2 receptor and continued to inhibit the tyrosine phosphorylation through 6 hours. ALW-II-41-27 also dose-dependently inhibited the EPHA2 phosphorylation induced by ligand. When the EPHA2 was depleted by RNAi in NSCLC cell lines, cells were much less sensitive to ALW-II-41-27. Other sizes are also available. Please inqury us for quote.
Cayman Chemical ANTIBODY IT-901 5mg
An inhibitor of the NF-κB subunit c-Rel; inhibits NF-κB DNA binding (IC50 = 0.1 µM); reduces TNF-α-induced NF-κB activity (IC50 = 4 µM); decreases proliferation of ABC and GCB DLBCLL cells at 3 µM; increases HO-1 expression and ROS production in mitochondria of DLBCL cells but not normal leukocytes; increases survival in a mouse model of GVHD at 24 mg/kg every other day beginning eight days after HSCT; reduces tumor growth in mouse xenograft models of EBV-induced B cell lymphoma, CLL, and Richter syndrome
Medchemexpress LLC MRX-2843 (UNC2371) | 1429882-07-4 | MFCD28502224 | 99.6% | 488.67 g/mol | C29H40N6O | 25 MG
MRX-2843 (UNC2371) is an orally active, ATP-competitive small-molecule inhibitor of the MERTK and FLT3 receptor tyrosine kinases used in preclinical research to study signaling, overcome resistance-conferring FLT3 mutations, and evaluate anti-leukemia effects. Analytical data and handling recommendations are provided for laboratory use.
- Potent dual MERTK and FLT3 enzymatic inhibition (IC50 1.3 nM and 0.64 nM).
- Demonstrated activity in cell proliferation assays (Kasumi-1 IC50 ≈ 143.5 nM).
- High purity suitable for research use (99.6% by HPLC).
- Orally active small molecule compatible with in vivo studies.
- Supplied as solid and solution formulations for flexible handling.
- Recommended storage: powder at -20°C or 4°C; in solvent at -80°C or -20°C.
- Molecular weight 488.67 g/mol; chemical formula C29H40N6O.
Medchemexpress LLC HY-W010841 10mg Medchemexpress, Levocetirizine (dihydrochloride) CAS:130018-87-0 Purity:>98%
Medchemexpress, HY-W010841 10mg Levocetirizine (diHCl) CAS:130018-87-0 Levocetirizine dihydrochloride ((R)-Cetirizine dihydrochloride) is a third-generation peripheral H1-receptor antagonist. Levocetirizine dihydrochloride is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine dihydrochloride has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
TARGETMOL CHEMICALS INC RCM-1 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RCM-1 is an inhibitor of FOXM1. purity: 99%
Cayman Chemical TPP-1hydrochlorIde 5mg
A peptide inhibitor of the PD-1-PD-L1 protein-protein interaction; binds to PD-L1 in a cell-free assay (Kd = 94.67 nM); reverses PD-L1-induced decreases in IFN-γ levels in anti-CD3-induced isolated human CD4+ T cells at 20 µM; reduces tumor volume in a mouse xenograft model using HL-60 leukemia cells co-cultured with anti-CD3-activated isolated human CD4+ T cells prior to implantation
Cayman Chemical ANTIBODY CP 346 086 1mg
An MTTP inhibitor (IC50 = 2 nM); inhibits ApoB and triglyceride secretion in HepG2 cells (IC50 = 2.6 nM for both); lowers plasma triglyceride levels, as well as plasma total, VLDL, and LDL cholesterol levels in rats at 10 mg/kg
Medchemexpress LLC HY-120801A 5mg Medchemexpress, APX-115 (free base) CAS:1270084-92-8 Purity:>98%
Medchemexpress, HY-120801A 5mg APX-115 (free base) CAS:1270084-92-8 APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with Ki values of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2 and Nox4, respectively. APX-115 free base effectively prevents kidney injury. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY RetIculol 5mg
A cAMP phosphodiesterase inhibitor (IC50 = 41 µM); inhibits DNA topoisomerase I at a concentration of 45 µM in B16F10 melanoma cells; has antifungal activity against T. mentagrophyes with a MIC 1.8 µM; cytotoxic against A427 human lung and B16F10 mouse melanoma cells at concentrations of 25 and 200 µM, respectively; inhibits lung metastasis in mice
Medchemexpress LLC Ala-Phe-Pro-pNA TFA | 99.9% | 453.49 | 5 MG
Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase and can be used to test tripeptidyl peptidase activity.
- Purity: 99.9%
- Molecular weight: 453.49 (free base)
- Chemical formula: C23H27N5O5.xC2HF3O2
- Appearance: Solid
- Color: White to off-white
- Sequence: Ala-Phe-{Pro-pNA}
- Sequence shortening: AF-{Pro-pNA}
- In vitro solubility: DMSO: ≥ 100 mg/mL
Medchemexpress LLC DL-lysine monohydrochloride | 70-53-1 | MFCD00064563 | 97.0% | 182.65 g/mol | C6H15ClN2O2 | 100 G
DL-lysine monohydrochloride is the hydrochloride salt of the amino acid lysine, supplied as a solid reagent for laboratory and biochemical research. It is commonly used in buffer preparation, cell culture supplementation, and biochemical assays where lysine or its salt form is required. The product is provided with purity specifications and supporting documentation such as a certificate of analysis and safety data sheet.
- Hydrochloride salt of DL-lysine for improved solubility in aqueous media.
- High purity (97.0%) suitable for analytical and research applications.
- Solid form, easy to handle, weigh, and store.
- Molecular weight 182.65 g/mol; formula C6H15ClN2O2.
- Supplied with certificate of analysis and safety data sheet for quality assurance.
- Suitable for buffer formulation, cell culture supplementation, and biochemical assays.
Medchemexpress LLC Amelenodor | 2389235-01-0 | >98.0% | 399.44 g/mol | C24H21N3O3 | 5 MG
Amelenodor (NX-13) is a small-molecule NLRX1 activator used in research on NOD-like receptor signaling and inflammatory pathways. The compound has the chemical formula C24H21N3O3 and molecular weight 399.44 g/mol, and is supplied in milligram quantities for in vitro and in vivo experimental use.
- NLRX1 activator for studies of innate immunity and inflammation.
- High purity suitable for research (>98%).
- Supplied in small-mass quantities appropriate for dosing and assay preparation.
- Stability data available for refrigerated and frozen storage conditions.
- Supporting documentation includes a data sheet and safety data sheet for handling guidance.