Bioactive Small Molecules
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Filtered Search Results
Medchemexpress LLC Simeprevir | 923604-59-5 | 98.79% | 749.94 | 100 MG
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Simeprevir (TMC435) is an oral, potent, and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor. It inhibits HCV replication and also potently suppresses SARS-CoV-2 replication, synergizing with Remdesivir. It inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and modulates host immune responses.
- Oral, potent, and highly specific inhibitor
- Inhibits HCV NS3/4A protease
- Suppresses SARS-CoV-2 replication
- Synergizes with Remdesivir
- Modulates host immune responses
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Medchemexpress LLC Maribavir | 176161-24-3 | 99.96% | 376.24 | 1 ML
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Maribavir is a potent inhibitor of histone phosphorylation catalyzed by wild-type pUL97 in vitro, with an IC50 of 3 nM. It also demonstrates potent antiviral activity against HCMV and Epstein-Barr virus (EBV).
- Potent inhibitor of histone phosphorylation.
- Demonstrates potent antiviral activity against HCMV and Epstein-Barr virus (EBV).
- For research use only.
- Multiple forms available.
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Apexbio Technology LLC DPN 1428-67-7 5mg
DPN (1428-67-7) is a non-steroidal agonist targeting estrogen receptor (ER ) It is designed to selectively bind and activate ER thereby modulating ER -mediated signal transduction DPN exerts its biological activity primarily through selective agonistic activation of ER DPN demonstrates high binding affinity with an EC50 value of approximately 0 85 nM Based on these pharmacological properties DPN holds research potential in neuroprotection and the study of neuropathological conditions
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Medchemexpress LLC S-acetyl-PEG3-alcohol | 153870-20-3 | MFCD22574787 | >98.0% | 208.28 g/mol | C8H16O4S | 5 MG
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S-acetyl-PEG3-alcohol is a short polyethylene glycol (PEG3) linker bearing an S-acetyl protected thiol and a terminal hydroxyl group. It is provided for research use and is commonly used as a spacer in the chemical synthesis of PROTAC molecules. Molecular formula C8H16O4S; molecular weight 208.28 g/mol.
- Provides a PEG3 spacer for linker construction.
- S-acetyl protects the thiol for controlled deprotection and conjugation.
- Terminal alcohol enables further functionalization or coupling reactions.
- Available in small research quantities suitable for medicinal chemistry.
- Suitable for PROTAC synthesis and linker optimization.
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Cayman Chemical CH5132799, Purity: ≥95%, CAS: 1007207-67-1, 5 mg
An inhibitor of class I PI3K isoforms (IC50s = 14, 120, 500, and 36 nM for PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ, respectively); selective for these PI3K isoforms over PI3KC2α, PI3KC2β, Vps34, and mTOR (IC50s = 5,300, >10,000, >10,000, and 1,600 nM, respectively), as well as 26 additional protein kinases (IC50s = >10,000 nM); inhibits proliferation of HCT116, KPL-4, T47D, and SKOV3 cells containing the PI3KαH1047R activating mutation (IC50s = 200, 32, 56, and 120 nM, respectively); reduces tumor growth in a PC3 mouse xenograft model at 25 mg/kg per day
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![Medchemexpress LLC (2E)-3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2-propenenitrile | 196309-76-9 | MFCD01862602 | 100.0% | 249.33 g/mol | C13H15NO2S | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000245844.png-250.jpg)
Medchemexpress LLC (2E)-3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2-propenenitrile | 196309-76-9 | MFCD01862602 | 100.0% | 249.33 g/mol | C13H15NO2S | 25 MG
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BAY 11-7085 is a small-molecule inhibitor that blocks NF-κB activation by preventing phosphorylation and promoting stabilization of IκBα. It is used in cellular and biochemical research to probe NF-κB signaling, apoptosis, and ferroptosis pathways.
- Inhibits NF-κB activation and phosphorylation of IκBα.
- Stabilizes IκBα with a reported IC50 of 10 μM.
- High reported purity (>99.9% by LCMS), suitable for research use.
- Solid form with good solubility in DMSO and ethanol.
- Commonly used in cellular and biochemical assays studying inflammatory and cell-death pathways.
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Cayman Chemical Atosiban, Purity: ≥98%, CAS: 90779-69-4, 10 mg
A peptide analog of oxytocin that antagonizes the human oxytocin receptor (Ki = 81 nM); has tocolytic actions in the acute phase of imminent preterm birth
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Cayman Chemical CB-7921220, Purity: ≥98%, CAS: 115453-99-1, 10 mg
An adenylyl cyclase 1 (AC1) and AC6 inhibitor; selective for AC1 and AC6, reducing their activity by 60% while having no effect on AC2 and AC5 in Sf9 membranes stimulated by forskolin (Item No. 11018) at 100 µM
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Selleck Chemical LLC Tetramethylcurcumin E2644-5MG
Tetramethylcurcumin (FLLL31) a small-molecule signal transducer and activator of transcription 3 (STAT3) inhibitor derived from curcumin binds selectively to Janus kinase 2 and the STAT3 Src homology-2 domain which serve crucial roles in STAT3 dimerization and signal transduction
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Medchemexpress LLC AI-10-104 | 1881276-00-1 | 98.9% | 5MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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AI-10-104 | 1881276-00-1 | 98.9% | 5MG
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Medchemexpress LLC FMAU | 1G
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FMAU is a thymidine analogue Analogs of this series have insertional activity towards replicated DNA They can be used to label cells and track DNA synthesis[1]
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Medchemexpress LLC GNE-235 | 3036574-72-5 | C13H16N4O | 5 MG
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GNE-235 is a compound selective for the second bromodomain of PBRM1, with a KD of 0.28 ± 0.02 μM. It can be used for evaluation of the cellular function of PBRM1.
- Selective for the second bromodomain of PBRM1
- Utilized for assessing the cellular function of PBRM1
- For research use only
- Epigenetic reader domain inhibitor
- Related to cancer, blood or cardio-cerebrovascular disease, and leukemia/lymphoma/myeloma
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Cayman Chemical ML-221, Purity: ≥98%, CAS: 877636-42-5, 25 mg
An APJ receptor antagonist (IC50 = 4.8 μM); selective for APJ over AT1 (IC50 = >78 μM); antagonizes apelin 13-induced activation of APJ in cAMP and β-arrestin recruitment assays (IC50s = 0.7 and 1.75 μM, respectively); inhibits proliferation and angiogenesis in Mz-ChA-1 cholangiocarcinoma cells from 5-15 μM; reduces tumor growth in a Mz-ChA-1 mouse xenograft model at 150 μg/kg; reduces sciatic CCI-induced mechanical allodynia and heat hyperalgesia in rats at 10 μg/animal; inhibits pathological angiogenesis and enhances normal vessel recovery in retinal ischemic regions in a mouse model of oxygen-induced retinopathy
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Cayman Chemical Isobutyryl-L-carnitine-d3 (chloride), Purity: ≥99% deuterated forms (d1-d3), 5 mg
An internal standard for the quantification of isobutyryl-L-carnitine by GC- or LC-MS
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Cayman Chemical EGTA, CAS: 67-42-5, 50 g
A chelating agent; selective for calcium over magnesium with Kapp values for calcium ranging from 6.93 to 10.7 x 105 M-1 in various buffers at pH 6.8 and 20°C; inhibits apoptosis induced by thapsigargin in isolated rat thymocytes at 5 mM; has been used as an irrigation agent to remove the smear layer from the pulp canal wall on extracted human teeth; intranasal administration enhances adenovirus-mediated gene transfer of LacZ to the trachea and main bronchi in mice by 8-fold
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